2 wk delivery Tolfenamic acid is a particularly powerful NSAIDwhich belongs to the phenamate family. Tolfine® is a solution for injectionbased on tolfenamicacid developed by Vétoquinol.Aagainst many diseases inboth cat and dogs: respiratory disorders, mastitis, MMA syndrome, arthritis,omphalectomy,... Its kinetics (entero-hepatic cycle) afterintramuscular injection (2 mg/kg: 5 ml/100 kg) make it effective for at least48 hours after intramuscular injection. For particularly acute infections,intravenous administration is preferred as it has a more powerful effect. Itcan be repeated at 24 hour intervals (2 mg/kg: 5 ml/100 kg) or given as asingle injection (4 mg/kg: 10 m/100 kg). - A powerful substance : after analysing existing substances, a powerful, analgesic, antipyretic,anti-inflammatory agent was chosen: tolfenamic acid. This substance, whoseanti-migraine properties are well known to doctors, was developed specificallyfor dogs and cats. The anti-inflammatory, analgesic and antipyretic potentialof Tolfedine® was exploited in the form of tablets and a solution forinjection. The range is adjusted to the animal’s weight as there are twodoses:6, and 60 mg. These doses mean that animals can be easily treated in divisionsof 1.5 or 15 kg of weight. - Fast-acting : beingfast-acting, Tolfedine® is one of the leading NSAIDs for all acute indications.Switching from oral forms to solutions for injection ensures that it can beeasily administered by the veterinarian at the consultation or during theanimal’s hospitalisation. - Well tolerated : withregard to chronic indications, Tolfedine® has proved to be completely effectiveand well tolerated in day-to-day veterinary practice and in numerous long-termtrials. This tolerance has been confirmed by very favourable pharmacovigilancereports over the years. Tests back up the results which have been obtained inpractice by a cox 2/cox 1 selectivity ratio of 15. Elimination is not alteredwhen the animal has renal insufficiency, nor does the dose have to be adjustedfor older animals, which is a guarantee of greater safety: 4 mg per kilogramper day for all ages! - Treating pain during surgery : some operations are known to be particularly painful: osteotomy,head surgery, ovariectomy, etc.. A recent study shows that administeringTolfedine® before surgery considerably increases the animal’s comfort and, as aresult, improves the animal’s return to consciousness from anaesthetics and thequality of its convalescence. - A licence for marketing the drug for dogs and cats : the veterinarian can legally prescribeTolfedine® because of the licence applying to dogs and cats, proving that it isextremely safe to use on two species whose metabolisms react differently tosome NSAIDs.
